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milchekyesterday at 11:27 AM9 repliesview on HN

Anecdotal, but about a year ago my wife participated in a psilocybin trial at a university here who were looking at patients with severe anxiety. It was her last hope after trying therapy, various supplements, as well as dietary and lifestyle changes, etc

It has been life changing for her, but one thing she tells people now is that what also helped was that it was facilitated with a trained therapist there during the session for guidance to make sure she didn’t “get stuck in a loop.” There was also many sessions pre dosing day to optimize the result.

She would highly recommend the treatment and hopes it becomes mainstream soon.


Replies

sampl3usernameyesterday at 12:40 PM

The point of music during a psychedelic experience is to provide a reference for the passing of time and to help with progression of thoughts. Music guides you through your thoughts, avoiding loops, by providing a changing texture, melody, rythm, and story.

This is on top of the other effects of music, such as emotional effects.

foobiekryesterday at 6:13 PM

Taking mushrooms together with someone you love, who loves you, is possibly one of the most life changing experiences a couple can have.

Have you taken them with her?

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Levitatingyesterday at 12:00 PM

> "get stuck in a loop"

I feel that. Thought loops are scary and it takes someone to recognize them to get you out.

sneaktoday at 3:23 AM

It’s also possible that the effect is purely pharmacological/physiological and the things you think or don’t think during the trip are entirely immaterial to its effects on depression and/or anxiety (which last days or weeks, whereas the hallucinogenic effects last only hours).

ThinkBeatyesterday at 3:00 PM

If I understand what you wrote correctly, Your wife did not try any traditional medication to treat her anxiety? Or is that included under "supplements"?

If so the term "lost hope" is not in my opinion accurate.

I am quite happy that it worked and it is a better alternative than medication, I certainly do not think that medication is the cure all, or optimal.

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say_it_as_it_isyesterday at 6:43 PM

Trial eligibility required someone with documented evidence of treatment-resistant depression, with at least two prescription regiments in recent history.

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Traubenfuchsyesterday at 3:36 PM

Technically, what is the approximate dosing regime?

How often, for how many days, how much (=how high?)?

Is this a therapy with an end or do you have to take mushrooms forever?

strnjrloopsyesterday at 1:43 PM

[dead]

AndrewThrowawayyesterday at 11:33 AM

Was she in placebo group?

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