alt Hacker Newssounds like in that case you’re not testing the efficacy of high versus sober, you’re testing heroic dosing versus micro dosing.
sounds like in that case you’re not testing the efficacy of high versus sober, you’re testing heroic dosing versus micro dosing.
There are also studies that test against placebo. There have been lots and lots of trials on these things with different designs that make different cost/benefit tradeoffs.
A difficult one with psychedelics is as-mentioned: people can easily "break the blind". But if you want to eliminate that problem you can instead do a micro vs macro dose, in which case you're measuring a slightly different thing.