Due to a small, self-selected sample, biased toward educated, prior hallucinogen users, inadequate blinding, p-hacking via uncorrected multiple tests on 17+ outcomes, and crossover design flaws that confound long-term effects with intensive therapy.

Similar psychedelic therapy claims—for LSD/psilocybin alleviating cancer-related anxiety/depression—have echoed since the 1950s-1970s, yet they've never panned out into practical, scalable clinical therapies. This alone should raise a MASSIVE Bayesian statistics red flag, due to prior discount: with decades of unfulfilled hype. At this point new evidence requires extraordinary proof to update our view.

If such massive effectiveness were true, it would blow what we already have out of the water, and I would be the first to promote it to my patients. But you know what they say when something sounds too good to be true.