With their stance of permacomputing, you don't think the two go hand in hand? A simple VM that can be implemented quickly on almost any hardware or underlying tech stack you can scrounge together? The only thing they'd be really against is designing new hardware to run Uxn "natively," which would seem to push you exclusively to reuse what you have.
100r's Uxn/Varvara aspires to be that, but that's not the same thing as succeeding at it. AFAIK the smallest computer with a full Uxn/Varvara implementation is a Nintendo DS [correction! Game Boy Advance], which is faster than the Sun workstation I was using in the 90s (though it has less RAM). You probably aren't going to get it running on an eZ80-based TI calculator, for example, or an Arduino UNO.
It's a good first step in that direction, the first attempt at permacomputing good enough to criticize.