It's open to things like sport and entertainment, so definitely not everyone has many (or any) degrees. Assuming your field is somewhat science based I don't know how realistic it would be with no degree, but you can search some blogs about it, people have covered what they did to rack up publications and stuff to check all the boxes (if their work/field wouldn't have otherwise needed them).

If you are starting your own business, the treaty investor visa could also be a good route. It doesn't require as much investment as the investor green card; it is a nonimmigrant visa similar to the O-1.