alt Hacker News> Nobody other than crazy micro-dosers is taking mushrooms often enough to cause a change in receptor density
This is so frustrating to me. Why not just google it before you think you know more about this than someone studying it for ten years? Two things can change receptor density: time and dose.
A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain
https://pubmed.ncbi.nlm.nih.gov/33467676/
This is exactly why psychedelics last longer than prozac. It has less to do with half life and more to do with dose.
How is the mechanism not at least comparative to prozac since it is well know they both effect serotonin? The risk with psilocin is exactly the dose, as many people find out. And you thing there are not cardiac side effects from psychedelics?
A Case of Prolonged Mania, Psychosis, and Severe Depression After Psilocybin Use: Implications of Increased Psychedelic Drug Availability
https://psychiatryonline.org/doi/full/10.1176/appi.ajp.22010...
Worsening suicidal ideation and prolonged adverse event following psilocybin administration in a clinical setting: case report and thematic analysis of one participant's experience
https://pmc.ncbi.nlm.nih.gov/articles/PMC11698204/
Safety First: Potential Heart Health Risks of Microdosing
https://petrieflom.law.harvard.edu/2022/04/13/safety-first-p...
You've studied it for ten years and didn't notice that the pig brain receptor changes were only measured at +7 days and are replying to a comment about long term effectiveness vs. prozac (which takes weeks to really show impact)?
I have previously read that study. You should put it in context: for example, how quickly does the brain add A1 and A2 receptors for caffeine? (I already know the answer, but you might want to use it to contextualize that study).
The study about the woman co-administering venlafaxine (Effexor) which is an SNRI might be worth considering as non-representative.
Worsening suicidal ideation .. is not unique to _any_ antidepressant. Are you trying to suggest that this is somehow unique to psilocin? We were discussing prozac which is _well known to have this problem_. They got black box warnings for this reason.
As for the heart study, I mentioned this myself elsewhere, and SSRIs are showing the same issue: https://columbiasurgery.org/news/columbia-surgery-researcher... - much worse, however, because people take these drugs every day for decades.