alt Hacker NewsThe issue was not the gene therapy itself, but the delivery mechanism. They used a virus to administer the gene therapy, and this virus (like most bloodstream impurities) aggregates in the liver. At low doses this is fine, but at high doses, your body's immune response will be laser-focused on the liver, and you die from the side effects of this response.
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cyberax • yesterday at 8:04 PM
Lipid nanoparticles have exactly the same problem. They mostly concentrate in the liver.
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if it's so obvious that this is going to produce these side effects, then why on earth did they gamble ?
(because, it definitely look like gambling, like "investors are behind us right now, so we have the money to do it, so let's do it before money runs out")