logoalt Hacker News

barbarryesterday at 7:53 PM1 replyview on HN

I'm guessing they were looking for preferential delivery to certain cell types, and AAVs just happened to have best profile for those. If anything, LNPs might aggregate in the liver even more than AAVs, which can lead to even worse hepatotoxicity if an immune response happens.


Replies

sampl3usernameyesterday at 7:57 PM

I thought lipid nanoparticles were less prone to generate a immune reaction.

show 1 reply