Like covid wiped us all right? A deep understanding of our genes means we are more likely to quickly create successful defenses against future hostile organisms, again, the most "hackable" specimens, those in which we could accurately predict the effects of our changes in their genes (including its interactions with virus and vaccines).
And the same homogeneity means that developing a defense for any future hostile organism is much more straightforward, just like e.g. developing software that works on windows is much easier than developing software that works on windows, Linux and mac.
Sigh. Covid was a serious illness. We were lucky and able to leverage science that had been in development for a long time to vaccinate against it. We have a deep understanding of many immune mechanisms, and can effectively treat people against some diseases. Vaccines are super effective (until the virus evolves and then they aren't).
This is also happening with other types of pathogens - antibiotic resistant illnesses are on the rise because we used quickly created defenses to eliminate all but the strongest versions of them. We have very few effective anti-fungal medications, and most of those are very risky.
If we were good at developing defenses for homogeneity, farmers all over the world wouldn't be fungi destroying the monocultures we depend on for modern agriculture (bananas and corn are really great examples). Estimates are that as much of 30% of global crops are lost to fungal infections; I sincerely doubt that homogeneity is the panacea you assume it is.
we know genetic diversity is beneficial from observing nature (sexual reproduction has clear evolutionary advantages that you can look into yourself if you like). yours is an interesting hypothesis, but "developing a defense" is something that we get for free from genetic diversity. we can improve our odds of survival using technology, but culling genetic diversity in favor of gene hacking compatibility comes with some tough trade-offs since you're choosing to ~always adapt manually. not to mention the ethical concerns depending on how this condition arises.