You've studied it for ten years and didn't notice that the pig brain receptor changes were only measured at +7 days and are replying to a comment about long term effectiveness vs. prozac (which takes weeks to really show impact)?

I have previously read that study. You should put it in context: for example, how quickly does the brain add A1 and A2 receptors for caffeine? (I already know the answer, but you might want to use it to contextualize that study).

The study about the woman co-administering venlafaxine (Effexor) which is an SNRI might be worth considering as non-representative.

Worsening suicidal ideation .. is not unique to _any_ antidepressant. Are you trying to suggest that this is somehow unique to psilocin? We were discussing prozac which is _well known to have this problem_. They got black box warnings for this reason.

As for the heart study, I mentioned this myself elsewhere, and SSRIs are showing the same issue: https://columbiasurgery.org/news/columbia-surgery-researcher... - much worse, however, because people take these drugs every day for decades.