Oh there are a bunch of considerations.

You're going to want persistent storage on your server, not ephemeral. You'll also want NVME. A lot of the time you're going to end up on bare metal running a single server anyway.

You're going to have down time for migrations unless you're very clever with your schema and/or replicas.

Litestream for me at least is what makes SQLite viable for a web app as prior to that there wasn't a good replication story.

With litestream it's much easier to have a backup on standby. That being said where I have used it in production some amount of downtime has been acceptable so mileage may vary.