alt Hacker Newsfor those that do not know there is a herb that targets GLP-1...its called Berberine
And yes its over the counter....I currently take one dose per day at 1200mg
Replies
Interesting.
"Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways"
https://www.sciencedirect.com/science/article/pii/S000629521...
But buyer beware when it comes to getting berberine from over-the-counter supplements:
"Variability in Potency Among Commercial Preparations of Berberine"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807210/
Nine of the 15 tested products (60%) failed to meet the potency standards of 90% to 110% of labeled content claim, as commonly required of pharmaceutical preparations by the U.S. Pharmacopeial Convention. Evaluation of the relationship between product cost and the measured potency failed to demonstrate an association between quality and cost. Variability in product quality may significantly contribute to inconsistencies in the safety and effectiveness of berberine. In addition, the quality of the berberine product cannot be inferred from its cost.
Worse still,
"Preparation and Evaluation of Antidiabetic Agents of Berberine Organic Acid Salts for Enhancing the Bioavailability"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337101/
Berberine—an isoquinoline alkaloid isolated from the rhizome of Coptidis rhizome, Cortex phellodendri, and other plant species—possesses a variety of pharmacological effects, including anti-cancer, anti-hyperglycemic, anti-hyperlipidemic, antimicrobial, anti-inflammatory, and antioxidant activities. However, its absolute bioavailability is as low as 0.68%. Low bioavailability greatly restricts the clinical development of berberine.
How effective is it?
Source? https://www.mcgill.ca/oss/article/medical-critical-thinking/... (2023) disagrees with you:
> Neither is berberine any version of Ozempic, which is an analogue of glucagon-like-peptide-1 (GLP-1), a natural hormone that regulates blood sugar and helps people feel full. Berberine has nothing to do with GLP-1.
> Perhaps the most interesting laboratory finding, given the rising global tide of type 2 diabetes, is the control that berberine may exert over blood sugar. But there is a problem. Berberine is virtually insoluble in water and has low intestinal absorption which means it has poor bioavailability. […] Because of berberine’s poor bioavailability, supplements on the market are likely to be useless. However, some derivative of berberine, may yet make it to the physician’s prescription pad. But it won’t be for weight loss.