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pyrophane10/11/20243 repliesview on HN

One thing that it seems we are just starting to talk about with these drugs is the associated muscle and bone density loss. I'm concerned that this generation of GLP-1 early adopters will wind up more frail and suffer a lower quality of life in old age as a result.


Replies

cyberax10/11/2024

> One thing that it seems we are just starting to talk about with these drugs is the associated muscle and bone density loss.

Muscle loss is associated with _any_ kind of weight loss.

And GLP-1 drugs _improve_ the bone density: https://academic.oup.com/jcem/article/100/8/2909/2836097 It's likely simply because thinner people naturally move more.

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r00fus10/11/2024

My program strongly recommends some form of muscle training (pushups/weights/etc) as they see improvements from muscle development for weight loss and to counteract the muscle loss from losing weight.

The fact remains that having to carry around 50+ extra pounds of fat requires more muscle. When that requirement goes away so does your need for that musculature.

petesergeant10/11/2024

I've seen zero evidence that muscle loss from GLP-1-assisted weight-loss is any different to the muscle loss from simply eating less. Do you have a link to a study I've missed?