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cyberax10/11/20241 replyview on HN

> Does anyone have references on any explanation, or even partial explanation, on why this might be the case?

Not yet. The effect appears to be real, but it's too soon to tell: https://www.science.org/content/blog-post/ozempic-and-other-...

From my own anecdata, unnecessary impulsive eating probably reinforces the impulsive behavior. You start associating impulsive behavior with a reward.

GLP-1 not only removes that, but adds a slight negative reinforcement. Impulsive eating no longer brings reward, but makes you feel over-full. This can then down-regulates the pathways that lead to increased impulsive behavior.


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rootusrootus10/11/2024

Great description, thanks!

I won't sugarcoat my problems. I knew I wasn't hungry when I'd eat sometimes. I knew it would keep me overweight. I knew it wouldn't even feel great afterwards. And yet, more often than not I did it. And beat myself up over it every time. Very demoralizing, even without help from moralizing folks on the internet.

On tirzepatide the impulse is just gone. I feel like I can take it or leave it, and since the consequences of eating unnecessarily are quickly negative, I just don't do it.