alt Hacker News>It's not that "eat less and exercise more" doesn't work, it's that nobody does it
There are plenty of examples of people who've managed to lose weight through diet and exercise, it's not "nobody". Sure it's a small % success rate, but that's because it's not easy. Just like squatting or deadlifting 300 lbs, it's not easy to get there, but the vast majority of humans could if they decided to put the time and effort into it.
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Sure, I don't mean literally nobody, just 'nobody' in the statistical sense - from the comment I replied to, "the likelihood of going from severely obese to normal weight is 1 in 1667."
Would you apply the same analysis to people with depression who cured their depression by smiling more? It's not zero, it's just very hard. Ultimately both are chronic issues of the central nervous system. We know GLP-1s act on the GABAergic central nervous system.
I'm one of those examples. I've never been obese or really even overweight, but mid-2023, I noticed my clothes were no longer fitting, and I decided to take off some weight. I lost 20 pounds over the course a a few months and have managed to keep it off since. Body scans aren't accurate, but the 1 scan I took after losing the weight put me at 13% body fat.
It's one of the hardest things I've done. I'm no stranger to hard physical things - I've run marathons, raced cyclocross, done daily bike commuting through several Chicago winters, and I'd rate the weight loss as up harder than all of those. At the risk sounding too hubristic - if that's the effort it takes to lose weight, doing so is beyond the abilities of large swaths of the population. Not to mention that I have the time and financial resources to weigh my food, buy foods that were optimal for my diet (so much yogurt and chicken!), etc.
(As a side note, exercise isn't a very good way to lose weight in my experience. It's valuable to do for all sorts of other reasons, but I actually gained weight when training for my first marathon, while running 60-70 miles/week).