Dude, the mortality rates go up at least linearly, maybe super-linearly, to weight over a certain amount. It's not like some mythical / hard to read / later benefit. This is a drug that radically changes those risks NOW, really quickly. It's a different matter than aspirin (helpful if heart disease is a real risk, otherwise no) or wine or smoking, both of which people have a strong interest in thinking of as good for you.