Had a friend with this problem. Wanted to say this story hits home for me after many many years. I tried my best to help, don’t want to say exactly how because I’m not qualified.

But frankly the doctor who prescribed larger and larger doses of Venlafaxine shouldn’t have been qualified either.

It’s a much more potent norepinephrine reuptake inhibitor than it is for serotonin. My understanding is by the time you get an effective dose you’ve got some collateral negative effects.