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wincy10/11/20242 repliesview on HN

Alternatively, as someone with severe ADHD, bupropion at the lowest dose gave me a psychotic episode where I started hearing things. Felt like I’d been dosed with schizophrenia pills. The razor blades told me to give them a look see. I threw them behind my fridge to keep them away. I went to my mom’s house, crawled in bed and cried for 24 hours straight. I’ve never had anything remotely like that before or since. This was nearly twenty years ago. Absolute worst day of my life.

My daughter had a pharmacogenetic screening test a few years ago and I’m not sure what this means exactly, but they give you a number with 1 being baseline expected response (this was awhile ago) and bupropion was a 9.

I’m extremely cautious about any sort of medication for me and my children because of this episode.


Replies

steve_adams_8610/12/2024

This is all very unsettling to read. Not only because of what happened to you, but because I had a terrifying experience with bupropion almost a year ago.

I’ve told myself I must have been at fault. I’m forgetful, I must have taken too much. I must have already been in a bad state. Whatever.

I quite literally almost died. I didn’t put anyone else at risk; nothing like it. But I went into a horrifying dark mental state and couldn’t imagine ever exiting it.

I tapered off and it took months to feel some semblance of normality again. I look back on it with a sense of fear. I genuinely lost my mind. I’ve taken psychedelics and even quite a lot of them at times and know the feeling of losing my ego and having a loss of control, but never have I felt so utterly disconnected and void.

I’ve wondered ever since how much this affects other people. Or how often it’s reported. I never told a soul until very recently.

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drzaiusx1110/13/2024

For the short time I was on Wellbutrin/bupropion I would have micro blackouts multiple time periods per day and couldn't recall what I did or where I was. Not for me. Sertraline on the other hand (SSRI) is a godsend.