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Alupis10/12/20241 replyview on HN

> We don't have any evidence to my knowledge of any long term risks with being on it.

Nobody has yet been on these drugs for an entire lifetime - which is what is being advocated in this thread.


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cthalupa10/12/2024

Sure. But what's the proposed mechanism? For many - not all, obviously - medications, we have an understanding of potential long term risks. Animal studies catch some of them, others we know are potentially risky even without animal studies, e.g. drugs that increase angiogenesis have a risk of increasing tumor growth.

But no one has proposed mechanisms for GLP1 peptides.

Meanwhile, we know obesity is one of the largest long term risks to health in existence, and one of the most prevalent.

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