>I think the lack of scientific, evidence-based examination and treatment pushed by MDs/DOs, therapists, and psychiatrists is a big part of the problem. There is not much in the way of nosology or real personalized medicine going on to understand specific root cause(s). It's just throw random medications and therapy approaches "spaghetti" against a wall and hope something sticks.

Totally agree. Think its a big problem and not enough study is being done on it (can't monetise it).

At least some of the medical professionals are willing to admit that the above is true. I'm pretty sure they've also put the words "treatment resistant depression" into my file.