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jvanderbot10/12/20241 replyview on HN

How will the person have less insulin resistance when GLP-1 medications stimulate the release of insulin?

It seems to me we're curbing eating by flooding with insulin, when one of the big damaging effects of overeating is insulin floods. (Or perhaps I'm misreading, perhaps insulin floods are only bad b/c they cause insulin resistance which causes more overeating?)


Replies

borski10/12/2024

You aren’t being flooded with insulin with the GLP-1 meds. You have food in your body, but my insulin levels, on average, are possibly lower than yours (if I’m in need or a GLP-1 med) despite eating the same amount.

A GLP-1 med stimulates the release of insulin slowly over a sustained period of time, not just as a massive spike when I eat.

Everyone (that isn’t diabetic) has a massive insulin spike when they eat something that spikes their glucose. GLP-1 meds don’t make that better in any way.