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csydas10/12/20243 repliesview on HN

I think some other posters already commented, but I wouldn't put too much stock in the MDMA being MDMA -- I use MDMA pretty frequently and never had brain zaps from it, but when I was on sertraline and quit without tapering off, I definitely had the brain zaps being described, and I still get them almost 15 years after discontinuing sertraline.

MDMA depending on where you are and what you got can be quite a few things, it's why test kits are important. It's not to say that MDMA cannot cause brain zaps, but given that we know that MDMA is usually cut with a lot of filler/other drugs without the user knowing, I would acknowledge it could do it, but would always have doubt it was actually the MDMA due to the knowledge that whatever the users who experienced brain zaps took likely had many other drugs/substances in it. In the current political climate surrounding drugs, I'm not even sure how a study could effectively be done correctly.

Which is unfortunate because brain zaps really suck and withdrawal from SSRIs is pretty rough. I easily get into addictive substances, and have successfully stopped use on quite a few pretty heavy things, and they didn't come close to the withdrawals from SSRIs for me. This is personal experience of course, and likely many other factors in my life helped with my stopping some recreational drugs without hugely adverse affects, but SSRIs just nothing helped and at the time (2010-2015), I really couldn't find any reliable information online or from doctors about the brain zaps.

I'm glad to read this article because it's great to see that there is attention to this and more focus on the side effects of SSRIs. SSRIs definitely can help many people, but it is pretty intense drug and the withdrawal is nasty for quite a few people.


Replies

zktruth10/12/2024

I don't know why you're so skeptical that a drug possessing the primary effect of flooding one's brain with serotonin can cause SSRI withdrawal symptoms upon cessation.

As for whether or not it's 'really MDMA', not everybody is popping pressed ecstasy tablets. It's trivial to send a few crushed crystals to a spectroscopy lab and I very rarely see samples cut with anything other than carbohydrates.

alan-hn10/13/2024

MDMA generally wouldn't cause the brain zaps after normal use (one 120-180mg dose), its usually high doses or abuse over multiple days that causes the changes necessary to feel these symptoms

mateus110/12/2024

What volume did you do? I took about the same amount as the OP and had it too.