People interested in FUSE might also be interested in the CUSE companion (sub)project.
CUSE is userspace character device driver emulation. It allows you to emulate hardware without compiling a new kernel module. I just used it recently to write a hardware device supporting IOCTLs using Python. However I didn't find any good Python libraries that worked easily and documentation was lacking, but I found it easy enough that I ended up writing it using just the ctypes ffi library. The only part that wasn't immediately intuitive for me, as someone who has never written kernel drivers, is how IOCTL's require the buffers to be resized for each read and write which means the calls come in pairs, but luckily CUSE has a debug mode which shows all bytes in and out. CUSE was originally implemented to create userspace sound devices¹ but has also been use for things like custom TTYs. I used it for creating a virtual SPI device. Hopefully someone finds this useful and this project can get more attention.