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sodality211/08/20242 repliesview on HN

I believe that it doesn’t work wholeheartedly, because every time I try it, it is ineffective - but my sinus problems are rarely bad enough to warrant medication (it’s been one year) and by then I’ve forgotten what works and what doesn’t.

Also, I suspect you’re mixing up your drugs. Phenylephrine (the drug in this article) lacks the methyl structure to be used for the synthesis of methamphetamines. In fact, that’s why it was popularized - pseudoephedrine, the truly effective sibling, was becoming too good for meth production, so they created a less potent alternative, phenylephrine, that lacks the ingredients necessary. They then locked pseudoephedrine behind the counter. Turns out the oral form of phenylephrine is less than “weaker” - it’s largely useless - so they pumped out enough of this crap to the tune of $1.7B that the American public spent every year for 18 years after they knew.


Replies

epcoa11/09/2024

> so they created a less potent alternative, phenylephrine,

Just to be clear, phenylephrine is not a “creation” or necessarily less potent. It’s an even older drug and a very effective vaso/venoconstrictor. The problem is it has poor oral absorption (bioavailability) as you note, so it doesn’t do much taken by mouth, but anything it does do is mostly deleterious. And thank god for that, because if it had the effect orally that it does via IV it would be killing a lot of people.

jart11/08/2024

Ah gotcha. So the cynical thing I thought would happen already happened.

Glad to hear we're on a road where peak cynicism is looking behind us.