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immibis11/08/20242 repliesview on HN

ESPECIALLY acetaminophen aka paracetamol aka Tylenol aka Panadol. This is the single drug with the smallest ratio between the effective does and the lethal dose, and it would not be approved today because of that. Oh, and you'll be fully conscious while you're dying and there's no known antidote.


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xienze11/08/2024

My Googling says 7.5g-10g is a lethal (acute) dose for an adult. The extra strength Tylenol pills come in 500mg, and they recommend two of those at a time. Not saying it's wrong that the gap between "effective" and "lethal" is small, but at the same time it's hard to accidentally take 15-20 pills at a time.

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Aerroon11/08/2024

>and there's no known antidote.

Isn't NAC (N-acetyl-cysteine) used for that?

https://www.ncbi.nlm.nih.gov/books/NBK537183/