You can use guix on any GNU/Linux distro afaik. If you create a guix profile for a project, it should be fairly simple to use that to install artanis. With guix time-machine you can also make reproducible setups, to ensure you can run your stuff years later.

But the most basic use of installing artanis in the default profile should also work.

Where do you see the difficulties installing artanis with guix?