alt Hacker NewsSo like, it's interesting that this happens in mice, but we did not see increased heart disease in human RCTs of these drugs.
Maybe the mouse dose is just absurdly high? "Mice were then administered semaglutide 120 μg/kg/d for 21 days." That could be vaguely reasonable -- human doses range from, idk, ~36 to ~200 μg/kg/d (2.5mg/week to 15mg/week at ~100kg).
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7e • today at 2:57 AM
They found the mice did not suffer from any heart problems, so it’s not surprising.
> but we did not see increased heart disease in human RCTs of these drugs.
In fact, we've even seen the opposite - that it's cardioprotective.