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cyberax11/21/20242 repliesview on HN

> For the people who lift weights while on this/these drugs, how much lean muscle do they lose?

I was 92kg when I started on liraglutide (I was doing GLP-1 agonists before it was cool!) and 67% of muscle mass (61kg). I'm now at 69kg and 82% of muscle mass (56kg). I'm doing weight and resistance training twice a week, in addition to aerobic training.

One nice thing, while muscles don't become more massive, they for sure become more pronounced and visible with weight loss.


Replies

scotty7911/21/2024

I'd bet you are stronger now despite slightly lower muscle mass.

Probably the muscle tissue people lose first are crappy cells. Weak, nonfunctional, senescent or even maybe some muscle embedded fat.

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metafunctor11/21/2024

Those muscle mass percentages cannot be right. How were they measured?

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