> Precompiled, portable binaries are the way to go which is what mise is built on.

And where are those mystery meat binaries supposed to come from? What do you do if the provided binaries aren't enough? (Wrong version, wrong build flags, what you want isn't even packaged, don't support your platform, etc, etc, etc.)

Binary package managers have been tried over and over, and never work out well.

> gives your system a "split-brain" problem where you have the "nix world" and the "macos (or whatever) world".

Yeah no, that's inherent as soon as you bring in any kind of secondary package manager. Including pyenv or mise or whatever else.