Not necessarily—perhaps it’s something like what we have right now is the residue of a slight variation from 50/50 in our local part of the universe (so it might have been 50.01% matter, 49.99% antimatter, and after the bulk of the matter and antimatter interacted and destroyed each other, the observable universe is that .02% left over. Do we know enough to be able to search for evidence of this in the cosmic background radiation?
My guesses are:
A universe that did that would have too much energy (from the mutual annihilation) once the orders and orders of magnitude of "extra" matter/antimatter interacted to make that likely/possible.
Wouldn't we also see clouds of antimatter just hanging around? What proportion of matter has ever interacted with anything else? My guess is "low".