Yes, very much looks like it.

I wonder how much of the second stage flight is autonomous and if they need to continually need to give it a go to continue, or if it aborts automatically after some time of lost telemetry. But maybe it already exploded anyways.

Space is hard.

"we currently don't have comms on the ship"

edit: the spacex stream just confirmed the loss.

That could have been kinda sorta intentional. No big deal.