I am actually optimistic that we might get the mini again now the 16e is priced at $599. There is a space for Mini at $499.
Part of the problem with Mini was its battery life. It seems 16e is improving on exactly that. Although I think it wont be 5.4" again since it was too small compared to the rest of the line up where it is usually 20% bigger screen to next size up.
May be 5.6" or even 5.8" as the original X.
I don’t think there is space, because the production costs of a mini model aren’t substantially lower. Remember that when the 12 mini launched, its price was the same as the 11, and the regular 12 got $100 more expensive.