The JIT will improve - you can also use PyPy to get speedups on programs that don't use a ton of C extensions.
Also, free-threading is coming so we'll have threads soon.
I don't know if Python can every really be fast as by design, objects are scattered all over memoryand even things like iterating a list, you're chasing pointers to PyObject all over the place - it's just not cache friendly.
PyPy has a list implementation that specializes under the hood. So if you stuff it with integers, it will contain the integers directly instead of pointers to them. That's at least how I understood it.