I've looked at F8's ISA reference and it has lots of instructions to support 16-bit numbers, including all the basic arithmetic and bitwise operations, plus loads/stores/pushes and pops. It's almost a 16-bit ISA, actually.
Which is just bizarre since, again, we have 8086, we have MSP430. And if you are fine with most of your data being 8-bit (which is not that uncommon), there is e.g. 8051 which is still quite popular.
This seems to be meant as pretty much 8051 replacement. 8051 cores are duct-tape of the modern computing and in almost anything, while 8051 is not exactly C-friendly architecture.