alt Hacker NewsThat is super interesting, as is the relationship between choline and sleep. With restorative sleep function, and specifically slow-wave activity, considered to be a significant driver of AD.
https://www.jarlife.net/3844-choline-sleep-disturbances-and-...
And then this ties to estrogen, HRT is known to reduce the risk of dementia/AD (https://pmc.ncbi.nlm.nih.gov/articles/PMC10480684/).
PEMT (phosphatidylethanolamine N-methyltransferase) is what makes choline in the body, but it depends on estrogen.(https://pmc.ncbi.nlm.nih.gov/articles/PMC3020773/)