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bilekas04/28/20252 repliesview on HN

Yeah it’s a really strange title for the actual work, it’s like saying bic pens helped find x y z simply because they used them to take notes.


Replies

tim33304/28/2025

>“It really demanded modern AI to formulate the three-dimensional structure very precisely to make this discovery.”

It's not like bic pens. It's a new technique they couldn't do before that helped crack the mystery.

Also the title is "AI Helps..." not "AI Discovers" so that's kind of a strawman. I don't think anyone is denying the humans did great work. Maybe it's more like Joe Boggs uses the Hubble telescope to find a new galaxy and moaning because the telescope gets a mention.

I'm quite enthusiastic about the AI bit. My grandad died with alzheimer's 50 years ago. My sister is due to die of als in a couple of years. Both areas have been kind of stuck for decades. I'm hoping the AI modeling allows some breakthroughs.

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dumb122404/29/2025

The paper has a much clearer title 'Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer’s disease'. This is from the univ press media page, it's very common to use over-hyped titles to draw views.