I think my problem is that this is maybe the most minimal and mundane use of AlphaFold, but it is treated like one of the main points of the paper. The small molecules they tested were already known to inhibit this enzyme, the structural modeling done based on AlphaFold is a minute part of the story compared to the dozens of incredibly difficult experiments they did - it almost seems the sort of thing one of the reviewers suggested during the initial submission and was added after the first round of edits.

I can't tell you how many times I've sat through talks where someone (usually ill-equipped to really engage with the research) suggests that the speaker tries AlphaFold for this or that without a clear understanding of what sort of biological insight they're expecting. It's also a joke at this point how often grad students plug their protein into AlphaFold and spend several minutes giving a half-baked analysis of the result. There are absolutely places where structure prediction is revolutionizing things including drug discovery, but can we acknowledge the hype when we see it?

I'm very sorry for your loss, my aunt is also declining due to this disease. I think statistically everyone either goes through it or becomes a caretaker if they live long enough.