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projektfulast Wednesday at 3:29 PM0 repliesview on HN

Except they are due to age. While lifestyle changes may make some conditions less likely or less severe, don't kid yourself into thinking you can avoid them all forever. Nor is lifestyle change an easy path for most people. If it were, many of the lifestyle diseases would be gone, because we know so much about them. Of the diseases in the article, only NASH (non-alcoholic steatohepatitis, called MASH in most of the article, presumably a typo) seems to be strongly related to lifestyle.

The government (or society, whatever) could reduce lifestyle diseases by closing the roads so that people do not drive, requiring jobs to be 50% physical, turning off electric lighting after 9pm, banning overly tasty packaged food, observing a sabbath, etc. Like that will ever happen. The studies are clear, so why don't we do this?

GLP-1 agonists are showing us that behavior has deeper roots than simple choice. People on these medications are able to choose the healthier choice without feeling something lacking, but when they are discontinued they typically return to old habits.

In the meantime, there have been successes at treating lifestyle diseases and giving people better, happier lives. I wish they could stop their behaviors, but I like that they have a chance to treat atrial fibrillation, coronary artery disease, etc.