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vdenis06/16/20251 replyview on HN

Hi, First time poster here, long time lurker, germline RUNX1-mutant myself. Father got AML, three decades of thrombocypenia for me, child is mutant as well, no event fortunately but under surveillance. Good news for your child!


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CobaltFire06/16/2025

Fortunately only his cancer was RUNX1, not his whole genome. It was also trisomy-21. Essentially he had what his doc described as the "stereotypical" B-ALL for individuals with Down Syndrome, but he doesn't have it.