logoalt Hacker News

esseph06/17/20255 repliesview on HN

I know people personally that psilocybin, LSD, and other substances do nothing for. All of them also have existing mental health disorders (extreme generalized anxiety, depression, bipolar, etc.).


Replies

tlavoie06/17/2025

That could be an interaction with the meds they take for those conditions, couldn't it? I seem to recall that SSRIs in particular could mitigate the effects of the hallucinogen.

show 2 replies
kbenson06/17/2025

Nothing as in there is no outside noticeable change in behavior and they report no change in speaking, or nothing as it relates to the topic of this thread, in that they have no profound or spiritual experiences?

show 1 reply
grigri90706/17/2025

Fwiw I find that, due to my antidepressants, i need 3x the dose to have the equivalent experience as my friends.

nathan_compton06/17/2025

I find mushrooms in particular delightful, just not deep.

show 1 reply
jdenning06/17/2025

Many psych meds diminish/block psychedelic effects.