I'm curious what are those use-cases where you really need it? I have DRM disabled since forever and never experience any problems that I can relate to that.
Music and TV/movie streaming, and that's about it afaict. I've got it disabled too, and I essentially never see issues unless I go to Netflix.
I think spotify doesn't work without it but I switched back to keeping all my music local long ago.
Which really makes you wonder why so many people fought hard to get it into the browser.