alt Hacker NewsThere's actually some issues with clock drift, and speculation whether or not original units had an accurate crystal or varied significantly in timing. The only way to figure that out is to go back and ask the designers what the original spec was, and who knows if they remember. So they're not really time-perfect, because the clock speeds can vary as much as a half-percent.
It's mostly the audio clock that is suspectible to drift. Everything except the audio subsystem is derived from a single master clock, so even if the master clock varies in frequency slightly, all the non-audio components will remain in sync with each other.
That means the 2 clock cycles could theoretically make an observable difference if they cause the CPU to miss a frame deadline and cause the game to take a lag frame. But this is rather unlikely.