Noise is definitely an issue.

I have an 8 drive NAS running 7200 RPM drives, which is on a wall mounted shelf drilled into the studs.

On the other side of that wall is my home office.

I had to put the NAS on speaker springs [1] to not go crazy from the hum :)

[1] https://www.amazon.com.au/Nobsound-Aluminum-Isolation-Amplif...