No, we can't be sure. There's a lot of diseases that we don't know the cause of, for example. Cancers, dementia, Alzheimer's, etc. There is a possibility that the rates of those diseases are higher because of plastics. Plastic pollution also accumulates, there was a lot less plastic in the environment a few decades ago. We add more faster than it gets removed, and there could be some threshold after which it becomes more of an issue. We might see the effect a few decades from now. Not only on humans, but it's everywhere in the environment now, affecting all life on earth.
You're not arguing in a way that strikes me as intellectually honest.
You're hypothesizing the existence of large negative effects with minimal evidence.
But the positive effects of plastics and social media are extremely well understood and documented. Plastics have revolutionized practically every industry we have.
With that kind of pattern of evidence, I think it makes sense to discount the negatives and be sure to account for all the positives before saying that deploying the technology was a bad idea.