It really depends on the size of the active set. If it fits into RAM of whatever server you are using, then it's not a problem at all, even with completely off-the-shelf hardware and software. Slap two 40gig NICs in it, install Varnish or whatever and you're good to go. (This is, of course, assuming that you have someone willing to pay for the bandwidth out to your users!)

If you need to go to disk to serve large parts of it, it's a different beast. But then again, Netflix was doing 800gig already three years ago (in large part from disk) and they are handicapping themselves by choosing an OS where they need to do significant amounts of the scaling work themselves.