alt Hacker News> Any security mechanism has a weakness or it will be bypassed by other means. So all this will give you a false sense of security.
> The moment you think you are safe. Is when you are most unsafe.
This is demonstrably false. Qubes OS has the lowest number of CVEs, even less than that of Xen. Last VM escape in it was found in 2006 by the Qubes founder (it's called "Blue Pill").
You are only thinking of attacking computer directly itself. Often people socially engineer access to a computer system. Many UK super markets were hacked, using some of the software that is very secure, because people managed to socially engineer access.
There is nothing and I mean nothing that is completely secure.