I don't find it to be a problem as planning a route from A to B isn't done by looking directly for it, but by subconsciously referring to and plotting a path through landmarks along the way that aren't close to antipodal.

One of the worlds i played on had road planning from the start and a set of roadways covering the entire world in a 4x4 square grid. Pathing to point D was just a matter of going 2 blocks in one direction, and 2 blocks in an orthogonal to it.

In a world without such roadways, you'd look for landmarks such as oceans and continents instead.

Ultimately, you don't care if somewhere is antipodal or not because you never see the antipodes to where the globe is currently looking at without rotating the globe.