Since it hasn't been mentioned here yet: I wonder if the multiple-memories feature will somehow allow to avoid the extra copy that's currently needed when mapping a WebGPU resource. This mapping is available in a separate ArrayBuffer object which isn't accessible from WASM without calling into JS and then copying from the ArrayBuffer into the WASM heap and back.
Multiple WASM memories and Clang's/LLVM's address space feature sound like they should be able to solve that problem, but I'm not sure if it is as trivial as it sounds...
I'm just getting horrible segmenting and far-pointer vibes of the whole thing, been coding a classic Gameboy game for fun so fiddling with memory mappings is part of the "fun" but for anything non-constrained I'd hate that.
We buried far pointers with DOS and Win16 for a good reason..
There has been a discussion (https://github.com/WebAssembly/multi-memory/issues/45) on the toolchain support, but I'm not sure if there have been steps to use multiple address spaces to support Wasm multi-memory in LLVM yet.