alt Hacker NewsSpoiler: there will be performance concerns.
The bottleneck is in the DOM operations themselves, not javascript. This is the reason virtual-dom approaches exist: it is faster to operate on an intermediate representation in JS than the DOM itself, where even reading an attribute might be costly.
This isn't true. DOM access is fast. DOM manipulation is also fast. The issue is many DOM manipulations happening all at once constantly that trigger redraws. Redrawing the DOM can also be fast if the particular DOM being redrawn is relatively small. React was created because Facebook's DOM was enormous. And they wanted to constantly redraw the screen on every single interaction. So manipulating multiple elements simultaneously caused their rendering to be slow. So they basically found a way to package them all into a single redraw, making it seem faster.