Somewhat related. At some point around 15 years ago I needed to work with large images in Java, and at least at the time the language used 32-bit integers for array sizes and indices. My image data was about 30 gigs in size, and despite having enough RAM and running a 64-bit OS and JVM I couldn't fit image data into s ingle array.

This multi-memory setup reminds me of my array juggling I had to do back then. While intellectually challenging it was not fun at all.